Promotion of Real-Time Analysis and Evaluation Platform Development
The research team led by Professor Sanghyuk Park from the Department of Smart Healthcare at Pukyong National University (President: Bae Sanghoon) has been selected for the "2025 Global Basic Research Laboratory (BRL) Support Program," organized by the Ministry of Science and ICT and the National Research Foundation of Korea.
Professor Park is participating in this project under the theme "Development of Advanced Bio-Organoid Non-Destructive Analysis Technology Based on AI-Linked SWE-ERS Integrated Platform," together with Professor Seungyun Nam (Department of Biomedical Engineering), Professor Wooram Eom (Department of Biotechnology), and Professor Changhan Yoon (Department of Biomedical Engineering, Inje University).
The Global Basic Research Laboratory program is a national initiative aimed at strengthening basic science capabilities by supporting small research groups focused on specific research topics. Through this selection, Professor Park's team will receive a total of 1.5 billion KRW in research funding over the next three years.
The research team aims to develop an evaluation platform capable of real-time, non-destructive analysis of the physical and biochemical properties of organoids. Organoids are three-dimensional biological tissues that mimic the structure and function of actual organs. While they have high potential for use in precision medicine and regenerative medicine, most current analysis methods are destructive, leading to high costs, significant time investment, and limitations in standardization.
Professor Park's team plans to develop a technology that determines tissue maturity by analyzing (ERS) RNA sequences inside exosomes secreted into the culture medium during organoid cultivation, and non-destructively measures changes in mechanical properties over time and location using 2D array-based shear wave elastography (SWE) technology. In addition, the team intends to apply AI analysis techniques to quantitatively assess the interconnections and correlations among the various analysis results.
Professor Sanghyuk Park stated, "This research will play a crucial role in securing core source technologies not only for organoids but also for implantable biomaterials and tissue-engineered organ manufacturing processes," adding, "We will lead basic research in the field of advanced regenerative biomedical engineering by collaborating with regional innovation leading research centers and key research institutes."
© The Asia Business Daily(www.asiae.co.kr). All rights reserved.
