ImmunisBio, Patent for 'Cell Culture Composition for Wound Healing' Utilizing Regulatory T Cells

[Asia Economy Reporter Hyungsoo Park] ImmunisBio announced on the 5th that it has registered a patent (10-2218211) for a "wound healing composition containing regulatory T cell culture fluid."

A company official explained, "The patent covers a culturing method that enables regulatory T cell culture fluid to have wound healing effects," adding, "Various anti-inflammatory cytokines and growth factors in the culture fluid produced using this technology promote the mobility of skin cells, restoring damaged skin cells."

As a result of treating with the culture fluid, it was confirmed that damaged cells are replaced by normal cells. It suppresses scar formation by reducing the expression of matrix metalloproteinases (MMPs), which are protein-degrading enzymes, and cadherin (E-cadherin), an adhesion protein. The expression and secretion of MMP-1 increase, activating extracellular matrix (ECM) degradation and tissue regeneration at the wound site. The culture fluid of regulatory T cells, which are immune cells, also participates in the inflammatory response that occurs when wounds happen, aiding rapid healing.

The composition not only has the effect of recovering the wound area but also has medicinal efficacy in soothing sensitive skin and alleviating atopic dermatitis.

Last year, ImmunisBio published research results in the international journal Clinical Cosmetic and Investigational Dermatology demonstrating that regulatory T cell culture fluid replaces damaged cells at wound sites with normal cells, thereby providing therapeutic effects.

CEO Jung-hwa Kang stated, "We plan to expand our product line to include functional cosmetics and dermacosmetics equivalent to pharmaceuticals containing cell culture fluid for skin regeneration, atopic relief, and anti-inflammatory effects." She added, "Along with the currently launched NK cell culture fluid cosmetic ‘Celresto,’ we will concretize products for acne and skin soothing, expanding the pipeline to include basic lines such as skin and lotion, as well as ampoules and mask packs."