Professor Jongho Lee's Team at Dong-A University Publishes Paper in Renowned International Journal and Selected as Hanbit Publishing Recommended Paper

Participation of Biomedical Department Master's Student Yoon Hyejin

"Provides Clues for Developing Next-Generation Anticancer Drugs, Significant Impact"

The research team led by Professor Lee Jong-ho of the Department of Biomedical Sciences at Dong-A University (President Lee Hae-woo) published a paper in the international journal specializing in oncology, Journal of Experimental & Clinical Cancer Research.

This paper, led by Yoon Hye-jin, a master's student in the Department of Biomedical Sciences at the university (first author), and Professor Lee, was selected as a recommended paper by the Biological Research Information Center (BRIC) under the "People Who Brightened Korea" (Hanbit-sa) series, which highlights outstanding papers by Korean scientists.

Journal of Experimental & Clinical Cancer Research is a world-class international journal specializing in oncology, with an impact factor of 11.4, reflecting its high prestige.

Professor Lee Jong-ho (left) and master's student Yoon Hye-jin at Dong-A University.

This research, supported by the Mid-Career Researcher Support Program of the Ministry of Science and ICT and the National Research Foundation of Korea, was conducted as an international collaborative study with research teams from Zhejiang University School of Medicine, Wenzhou Medical University, and Sichuan University.

The title of the paper by Professor Lee’s team is “AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth.”

In the paper, Professor Lee’s team explained, “Using glioblastoma, one of the most malignant brain tumors known today, we discovered that the serine biosynthesis metabolic pathway activated by AMPK-HIF-1α signaling is most active in the brain environment and plays a very important role in glioblastoma growth and survival.”

The research team also emphasized, “This study is significant in that it provides a foundational clue for developing new anticancer drugs targeting glioblastoma, which currently lacks effective treatments, by understanding the importance and precise activation mechanism of the serine biosynthesis metabolic pathway that plays a critical role in cancer cell growth and survival.”

Professor Lee stated, “We plan to conduct research to identify the molecular mechanisms of metabolism, growth, and survival that differentiate cancer cells from normal cells, and to propose new and promising therapeutic targets for the development of cancer metabolism therapies.”